Matrigel induces thymosin β4 gene in differentiating endothelial cells

نویسندگان

  • D. S. Grant
  • J. L. Kinsella
  • M. C. Kibbey
  • S. LaFlamme
  • P. D. Burbelo
  • A. L. Goldstein
  • H. K. Kleinman
چکیده

D. S. Grant1,*, J. L. Kinsella2, M. C. Kibbey1, S. LaFlamme1, P. D. Burbelo1, A. L. Goldstein2 and H. K. Kleinman1 1Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bldg 30, Rm 430, Bethesda, MD 20892, USA 2Laboratory of Cardiovascular Science, Gerontology Reseach Center, NIA, Baltimore, MD, USA 3Department of Biochemistry and Molecular Biology, The George Washington University Medical School, Washington, DC, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Verifiable Hypotheses for Thymosin β4-Dependent and -Independent Angiogenic Induction of Trichinella spiralis-Triggered Nurse Cell Formation

Trichinella spiralis has been reported to induce angiogenesis for nutrient supply and waste disposal by the induction of the angiogenic molecule vascular endothelial cell growth factor (VEGF) during nurse cell formation. However, the action mechanism to induce VEGF in nurse cells by T. spiralis is not known. Hypoxia in nurse cells was suggested as a possible mechanism; however, the presence of ...

متن کامل

Thymosin β4 promotes the survival and angiogenesis of transplanted endothelial progenitor cells in the infarcted myocardium

The survival of transplanted stem cells in ischemic tissue is poor. In the present study, the effects of thymosin β4 (Tβ4) on the survival and angiogenesis of endothelial progenitor cells (EPCs) and improvement in cardiac functions after transplantation of Tβ4-treated EPCs in the infarcted myocardium were investigated. EPCs were isolated from bone marrow of adult male rats and incubated in Endo...

متن کامل

Thymosin β4 induces the synthesis of plasminogen activator inhibitor-1 in cultured endothelial cells and increases its extracellular expression

http://bloodjournal.hematologylibrary.org/content/103/4/1319.full.html Updated information and services can be found at: (2497 articles) Hemostasis, Thrombosis, and Vascular Biology • (1086 articles) Gene Expression • (143 articles) Cytoskeleton • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_...

متن کامل

Thymosin β4 reduces senescence of endothelial progenitor cells via the PI3K/Akt/eNOS signal transduction pathway.

We previously demonstrated that thymosin β4 (Tβ4) regulates a variety of endothelial progenitor cell (EPC) functions, including cell migration, proliferation, survival and angiogenesis. However, the effect of Tβ4 on the senescence of circulating EPCs remains unclear. In the present study, the effect of Tβ4 on EPC senescence and the signal transduction pathways involved in this process was inves...

متن کامل

Thymosin β4 in rheumatoid arthritis: Friend or foe.

Rheumatoid arthritis (RA) has characteristic pannus tissues, which show tumor-like growth of the synovium through chronic joint inflammation. The synovium is highly penetrated by various immune cells, and the synovial lining becomes hyperplastic due to increased numbers of macrophage-like and fibroblast-like synoviocytes. Thus, a resultant hypoxic condition stimulates the expression of inflamma...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1995